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U.S. Department of Health and Human Services
Sexually Transmitted Infections (STI)

Syphilis Statistics

Syphilis rates among American Indian and Alaska (AI/AN) people had the largest increase in primary and secondary syphilis of all racial/Hispanic ethnicity groups between 2018 and 2022. Congenital syphilis rates have increased for five straight years among AI/AN people, resulting in the highest rates of congenital syphilis of any racial/Hispanic ethnicity group in 2022.

View the latest data on Syphilis Exit Disclaimer: You Are Leaving www.ihs.gov  from the Centers for Disease Control and Prevention (CDC).

Key Statistics about Syphilis among American Indian/Alaska Native People

  • Rates of primary and secondary syphilis among AI/AN people increased from 11 per 100,000 in 2017 to 67 per 100,000 in 2022.
  • Rates of congenital syphilis among AI/AN people increased from 101.8 per 100,000 to 644.7 per 100,000 in 2022.
  • In 2022, AI/AN people represented 0.7% of live births, but they accounted for 4.6% of all congenital syphilis cases.

CDC Reported Rates

Excerpt from CDC data, 2018 to 2022. In 2019, primary and secondary syphilis rates by population per 100,000 people from lowest to highest were among Asian, White, Multiracial, Hispanic/Latino, American Indian/Alaska Native, Native Hawaiian/Pacific Islander, and Black/African American populations. By 2022, AI/AN had the highest rates, jumping from about 20 cases to about 70 per 100,000 people.

CDC Reported Syphilis rates 2019-2022

Additional Data Resources

AtlasPlus Exit Disclaimer: You Are Leaving www.ihs.gov  is an interactive tool from the CDC that allows users to create customized tables, maps, and charts on HIV, viral hepatitis, STDs, and TB. AtlasPlus also provides access to indicators on social determinants of health (SDOH), allowing users to view social and economic data in conjunction with surveillance data for each disease.