NOTICE
Per a court order, HHS is required to restore this website as of 11:59 PM, February 14 2025. Any information on this page promoting gender ideology is extremely inaccurate, and disconnected from the immutable biological reality that there are two sexes, male and female. The Trump Administration rejects gender ideology and condemns the harms it causes to children, by promoting their chemical and surgical mutilation, and to women, by depriving them of their dignity, safety, well-being, and opportunities. This page does not reflect biological reality and therefore the Administration and this Department rejects it.
2SLGBTQ Health Information and Resources

Two-Spirit/LGBTQI+ people have all the same health concerns as everyone else, but may also face disparities in care, discrimination, and obstacles to and stigma about getting treatment.
The 2015 U.S. Transgender Survey: Report on the Experiences of American Indian and Alaska Native Respondents [PDF - 1.6 MB] report outlines aspects of AI/AN respondents' identities and demographic characteristics, such as gender, age, geographic location, and educational attainment, to provide important context for their experiences.
The 2022 U.S. Trans Survey: Early Insights [PDF - 3.4 MB] – is the largest survey of trans people, by trans people, in the United States.

Transgender and Gender Diverse Persons – CDC LGBT Health pages
Fast Facts: HIV and Transgender People - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
The National LGBT Cancer Action Plan: A White Paper of the 2014 National Summit on Cancer in the LGBT Communities – LGBT Health
Cancer Facts for Lesbians and Bisexual Women – The American Cancer Society
Cancer Facts for Gay and Bisexual Men – The American Cancer Society
Mental Health

Stigma and discrimination can increase the burden of mental health issues on Two-Spirit/LGBTQI+ people, who can suffer from the same conditions as everyone else, but have unique experiences and feelings that require appropriate treatment.
- The Health of Lesbian, Gay, Bisexual, and Transgender People: Building a Foundation for Better Understanding - National Academies
- Mental Health in Lesbian, Gay, Bisexual, and Transgender (LGBT) Youth – Annual Review of Clinical Psychology
- National Alliance on Mental Illness: Find Support for LGBTQ
HIV
AI/AN gay, bisexual, and Two-Spirit males, especially those on reservations or in rural areas, may face culturally based stigma and confidentiality concerns that interfere in learning about HIV prevention and getting HIV testing. Cultural differences, beliefs, and practices may also be an obstacle, with more 200 different languages spoken across more than 500 federally recognized AI/AN tribe. Other barriers may include socioeconomic issues, substance use disorders, and mistrust of government health care and the government itself.