Update on Biosimilar Insulins for Diabetes Management

1. To reduce nocturnal hypoglycemic events Degludec is favored over Glargine U100.

a) True
b) False

2. Lantus and Semglee are Glargine U100 biosimilars and are interchangeable.

a) True
b) False

3. Humulin U-500, a highly concentrated insulin, is indicated if the total daily dose of insulin is >200 units per day.

a) True
b) False

4. Insulin resistance has the following characteristic(s):

a) Increased glucose production
b) Decreased peripheral muscle uptake
c) Increased lipolysis
d) All of the above

5. Lyumejev and Admelog are lispro biosimiliars that are NOT interchangeable.

a) True
b) False

6. The following is/are challenge(s) patients face in regards to optimal insulin therapy:

a) Fear of taking insulin
b) Health beliefs regarding insulin
c) Complexity of the insulin regimen
d) Cost
e) All of the Above

7. If your patient has nocturnal hypoglycemia, it is recommended to switch to a long-acting analog versus using NPH.

a) True
b) False

8. The following is/are signs there is too much basal insulin on-board:

a) HS to AM blood glucose drop of more than 50 points
b) Large post-prandial to pre-prandial differentials
c) Basal dose >.5 units/kg/day, and not taking prandial insulin
d) High variability in blood glucose numbers
e) All of the above

9. It is helpful to consider prandial insulin over other post-prandial medications when a patient has pancreatic insufficiency.

a) True
b) False