Managing Diabetes in Children

1. Unlike adult onset Type 2 Diabetes (T2DM) where there is little difference between men and women getting diabetes, youth-T2DM is female dominant in regards to onset.

a) True
b) False

2. Metabolic syndrome and insulin resistance are two driving facts typically seen in youth-onset T2DM.

a) True
b) False

3. More children with youth-onset T2DM experienced treatment failure with metformin initiation than adults during the same duration of treatment.

a) True
b) False

4. The following is/are long-term complications of youth-onset T2DM:

a) Hypertension
b) Kidney Disease
c) Dyslipidemia
d) Nerve diseases
e) All of the above

5. The RISE study found that youth make more C-Peptide and insulin in response to similar glycemic stimuli compared to adults.

a) True
b) False

6. Which of the following is/are differences in T2DM in youth compared to adults:

a) Youth have more severe insulin resistance compared to equally obese adults
b) Beta-cell dysfunction in youth is less responsive to metformin and glargine
c) Beta-cell function in youth is hyperresponsive compared to adults
d) All of the above

7. One study found that two years of metformin treatment in obese youth during puberty improved BMI and body fat, but not insulin-resistance or B-cell function.

a) True
b) False

8. The TODAY study found that Thiazolidinedione’s (TZDs) in youth had the following response(s):

a) Decreased inflammation
b) Improved peripheral and hepatic insulin sensitivity
c) Increases adiponectin
d) Increases insulin clearance
e) All of the above

9. The TODAY study found that an A1c > 6.3% is a good predictor indicating the likelihood to lose glycemic control.

a) True
b) False