Community Opioid Intervention Prevention Program

Tianeptine, a tricyclic antidepressant available overseas, has not been approved by the U.S. Food and Drug Administration for any medical use and is not legally available here.

Products containing tianeptine are illegally being sold and promoted in the U.S., often in health supplements with unproven health claims, and can lead to misuse, dependence, overdose, and death.

U.S. Poison control center cases of severe side effects involving tianeptine have and continue to increase, from 11 total cases between 2000 and 2013 to 151 cases in 2020.

Read and download the IHS Alert on Tianeptine flyer. [PDF 302 KB]